Top 5 Takeaways Nitazene Potency and Prevalence: Nitazenes, potent illicit synthetic opioids, have been increasingly found in toxicology reports and death certificates, with some analogs more potent than fentanyl. Surveillance

Top 5 Takeaways: Median monthly overdose deaths among adolescents aged 10-19 years increased by 109% from July–December 2019 to July–December 2021. Deaths involving illicitly manufactured fentanyls (IMFs) rose by 182%,