Top 5 Takeaways High Prevalence of SCD Among Caregivers: Approximately 12.6% of unpaid caregivers aged ≥45 years reported subjective cognitive decline (SCD), compared to 10.2% of noncaregivers. Health and Demographic

Top 5 Takeaways Increase in Synthetic Opioid Overdose Deaths: Overdose deaths involving synthetic opioids, primarily illicitly manufactured fentanyl, have increased approximately tenfold since 2013 and accelerated during the COVID-19 pandemic.

Top 5 Takeaways Increased Risk: Pregnant and recently pregnant women are at higher risk for severe illness and death from COVID-19 compared to non-pregnant women. COVID-19–Associated Deaths: Mississippi reported 15

Top 5 Takeaways Low PrEP Awareness: Only 32.3% of heterosexually active adults in high HIV prevalence cities were aware of PrEP, and less than 1% used it. Disparities Among Hispanic

Top 5 Takeaways High Prevalence of Early Sexual Debut: Between 14.4% and 40.1% of adolescent girls and young women in the nine PEPFAR countries had early sexual debut. Increased Risky

Top 5 Takeaways Low Vaccination Coverage: Full COVID-19 vaccination coverage among persons experiencing homelessness ranged from 18.6% to 44.5%, significantly lower than the general population in the same jurisdictions. Data

Top 5 Takeaways Disparities in HIV Infections: While new HIV infections decreased among White MSM from 2010 to 2019, they did not decrease among Black MSM or Hispanic/Latino MSM. Age-Related