Top 5 Takeaways Sharp Increase in Deaths: IMF-involved overdose deaths surged in midwestern (33.1%), southern (64.7%), and western (93.9%) regions during 2019-2020. Polysubstance Use: Approximately 40% of IMF-involved deaths also

Top 5 Takeaways High Booster Uptake: 18.7 million adults aged ≥65 years received a booster or additional primary dose, representing 44.1% of eligible individuals in this age group. Coverage Variation:

Top 5 Takeaways Provider Recommendations Increase Vaccination Rates: Adults who received a COVID-19 vaccination recommendation from a health care provider were more likely to have been vaccinated (77.6%) compared to

Top 5 Takeaways Test to Stay (TTS) Implementation: 90 schools in Lake County, Illinois, implemented the TTS strategy during fall 2021, allowing close contacts with masked COVID-19 exposures to remain

Top 5 Takeaways TTS Adoption: One in five public schools in Los Angeles County adopted the Test to Stay (TTS) strategy, allowing students exposed to COVID-19 to remain in school

Top 5 Takeaways High Hospitalization Rates: 77.9% of children and adolescents hospitalized during the study period were admitted for acute COVID-19. Viral Coinfections: Approximately one third of children under 5

Top 5 Takeaways High Vaccine Effectiveness: The Pfizer-BioNTech vaccine showed 92% effectiveness in preventing SARS-CoV-2 infection among adolescents aged 12–17 years under real-world conditions. Study Design: A prospective cohort study

Top 5 Takeaways Common Reactions: Local and systemic reactions were frequently reported in children aged 5–11 years after Pfizer-BioNTech COVID-19 vaccination, especially after the second dose. Nonserious Events: Approximately 97.6%