Top 5 Takeaways Lower Vaccine Effectiveness: The effectiveness of mRNA vaccines against COVID-19-associated hospitalization was lower among immunocompromised adults (77%) compared to immunocompetent adults (90%). Variation Among Subgroups: Vaccine effectiveness

Top 5 Takeaways Additional Primary Dose for Immunocompromised: ACIP recommends an additional mRNA COVID-19 vaccine dose for moderately to severely immunocompromised individuals. Booster Dose Recommendations: ACIP recommends a COVID-19 vaccine

Top 5 Takeaways Higher Odds of COVID-19 in Previously Infected: Unvaccinated adults with previous SARS-CoV-2 infection had 5.49 times higher odds of laboratory-confirmed COVID-19 compared to fully vaccinated individuals without