Top 5 Takeaways Highest Risk Group: Unvaccinated individuals without a previous COVID-19 diagnosis had the highest rates of COVID-19 cases and hospitalizations. Impact of Delta Variant: After the Delta variant

Top 5 Takeaways Higher Vaccination Coverage Among Gay or Lesbian Adults: Gay or lesbian adults reported higher COVID-19 vaccination coverage (85.4%) compared to heterosexual adults (76.3%). Gender Differences in Vaccination:

Top 5 Takeaways Increased Vaccine Effectiveness: A third dose of mRNA COVID-19 vaccines significantly increased vaccine effectiveness (VE) against hospitalization from 82% to 97% in immunocompetent adults and from 69%

Top 5 Takeaways Higher Risk for Unvaccinated: Unvaccinated individuals had significantly higher COVID-19 incidence and hospitalization rates compared to vaccinated individuals, especially those with a booster. Omicron Impact: During Omicron

Top 5 Takeaways Rural-Urban Health Disparities: Working-aged adults in small/medium urban and rural counties reported worse physical health compared to those in large urban counties. Socioeconomic Factors: Differences in socioeconomic

Top 5 Takeaways Higher Fatigue in Adolescents: In 2020, 10.9% of adolescents aged 12–17 years reported being tired most days or every day, compared to 3.5% of children aged 5–11

Top 5 Takeaways Consistent Mask Use Reduces Infection Risk: Consistently wearing a face mask or respirator in indoor public settings was associated with lower odds of testing positive for SARS-CoV-2.

Top 5 Takeaways Omicron vs. Delta Severity: Patients hospitalized during the Omicron period had less severe illness compared to those during the Delta period, largely due to higher vaccination rates.