Top 5 Takeaways

1. Updated Protocols: On December 16, 2021, the NFL updated its test-to-release protocols in response to the surge in COVID-19 cases and the predominance of the Omicron variant.
2. Testing Results: Among 173 fully vaccinated individuals with COVID-19, 46% received a negative or high cycle threshold RT-PCR test result by day 6 postdiagnosis.
3. Isolation and Return: 84% of the individuals had a negative or high cycle threshold RT-PCR test result by day 10, allowing them to return to work under NFL protocols.
4. Precautionary Measures: Despite negative test results, individuals should continue to take precautions, including wearing masks for a full 10 days after symptom onset or initial positive test result.
5. High Vaccination Rates: The NFL had a high vaccination rate, with over 96% of its population vaccinated by October 2021.

Original Article Author and Citation

Corresponding Author

Christina D. Mack, Christina.Mack@iqvia.com

Suggested Citation

Mack CD, Wasserman EB, Killerby ME, et al. Results from a Test-to-Release from Isolation Strategy Among Fully Vaccinated National Football League Players and Staff Members with COVID-19 — United States, December 14–19, 2021. MMWR Morb Mortal Wkly Rep 2022;71:299–305. DOI: http://dx.doi.org/10.15585/mmwr.mm7108a4

Summary

This report examines the NFL’s updated test-to-release from isolation strategy for fully vaccinated players and staff during the Omicron surge in December 2021. The study found that 46% of the 173 fully vaccinated individuals with COVID-19 received a negative or high cycle threshold RT-PCR test result by day 6 postdiagnosis, and 84% by day 10. These findings support the continued use of precautions, including mask-wearing, for 10 days post-symptom onset or initial positive test result.

Methods

The study analyzed data from the NFL’s SARS-CoV-2 testing program during December 14–19, 2021. Fully vaccinated individuals were tested daily, and isolation ended after two negative or high cycle threshold RT-PCR test results. The analysis included 173 individuals who met the testing criteria, with data reviewed by IQVIA and supported by the CDC.

Discussion

The findings indicate that while a significant portion of individuals tested negative by day 6, continued precautions are necessary due to the potential for positive RT-PCR results beyond this period. The study supports CDC recommendations for mask use for 10 days post-symptom onset or initial positive test result. Limitations include the specific population studied (predominantly adult men in an occupational setting) and the inability to assess subsequent transmission post-isolation.

Conclusion

The NFL’s test-to-release strategy showed that a significant portion of fully vaccinated individuals could safely return to work before day 10 postdiagnosis. However, continued mask use and precautions are essential to prevent potential transmission. These findings align with CDC guidelines and emphasize the importance of ongoing vigilance even after negative test results.

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